In heterozygous FH, the LDL level range is typically?

In heterozygous FH, the LDL level range is typically?

• A. 100-150 mg/dL
• B. 200-250 mg/dL
• C. 250-290 mg/dL
• D. 300-350 mg/dL

Answer: (D)

Heterozygous familial hypercholesterolemia causes LDL cholesterol to stay very high because the body’s ability to clear LDL particles is impaired. Normal LDL-C is generally under 100 mg/dL, so levels in FH fall well into the hundreds. In heterozygous FH, the typical range is in the hundreds, often around 300 mg/dL or higher. The 300–350 mg/dL range best reflects this marked elevation, whereas the lower ranges (100–150, 200–250, 250–290 mg/dL) are not as consistent with the substantial LDL-C rise seen in FH. This elevated LDL-C is a key reason for the increased cardiovascular risk in these patients.

Heterozygous familial hypercholesterolemia causes LDL cholesterol to stay very high because the body’s ability to clear LDL particles is impaired. Normal LDL-C is generally under 100 mg/dL, so levels in FH fall well into the hundreds. In heterozygous FH, the typical range is in the hundreds, often around 300 mg/dL or higher. The 300–350 mg/dL range best reflects this marked elevation, whereas the lower ranges (100–150, 200–250, 250–290 mg/dL) are not as consistent with the substantial LDL-C rise seen in FH. This elevated LDL-C is a key reason for the increased cardiovascular risk in these patients.